Sulfite as the substrate of C-sulfonate metabolism of α, β-unsaturated carbonyl containing andrographolide: analysis of sulfite in rats' intestinal tract and the reaction kinetics of andrographolide with sulfite / 中国天然药物

One-sixth of the currently known natural products contain α, β-unsaturated carbonyl groups. Our previous studies reported a rare C-sulfonate metabolic pathway. Sulfonate groups were linked to the β-carbon of α, β-unsaturated carbonyl-based natural compounds through this pathway. However, the mechanism of this type of metabolism is still not fully understood, especially whether it is formed through enzyme-mediated biotransformation or direct sulfite addition. In this work, the enzyme-mediated and non-enzymatic pathways were studied. First, the sulfite content in rat intestine was determined by LC-MS/MS. The results showed that the amount of sulfite in rat intestinal contents was from 41.5 to 383 μg·g

Corrigendum to “Metabolic profiling of icaritin in rats using UHPLC-Q/TOF-MS” Chinese Herbal Medicines 11 (2019) 185–191 (Chinese Herbal Medicines (2019) 11(2) (185–191), (S1674638419300255), (10.1016/j.chmed.2019.03.008)) / 中草药·英文版

When this paper was first published the following ethical statement was omitted in error: The studies were approved by the Animal Ethics Committee of Tianjin University of Traditional Chinese Medicine. The animals were cared according to the regulations of the Animal Ethics Committee. The authors would like to apologise for any inconvenience caused.